An international study, carried out by the Universitat of Barcelona (Spain), Max Planck Institute of Experimental Medicine (Germany) and the University of Newcastle (United Kingdom), in collaboration with several universities and institutes in Spain, identified a molecule that stops and reverses the neurodegeneration caused by Parkison’s disease.
Researchers found the molecule that might halt the evolution of Parkinson’s disease and repair the damages
This finding came after the researchers analyzed more than 14,000 molecules, out of which, only one, called SynuClean-D, seemed to prevent the Parkinson’s disease evolution.
The study was conducted on Caenorhabditis elegans worms, the most used ones for the study of neurodegenerative diseases, and showed that the so-called SynuClean-D molecule reduces remarkably the aggregation of alpha-synuclein, the protein that accumulates in the neurons that generate dopamine, which is the main characteristic of the Parkinson’s disease.
Scientists are hopeful that their solution would be used to treat neurodegenerative diseases in the future
Likewise, the study has also confirmed that the administration of this SynuClean-D molecule, an inhibitor for the synuclein molecules that build up in the brains of the patients with Parkinson’s disease, improved the mobility of the animal subjects and protected their brains from neuronal degeneration.
One of the research coordinators, Salvador Ventura from the University of Barcelona, pointed out that the finding “may have therapeutic applications to treat neurodegenerative diseases such as Parkinson’s in the future.”
The international research enjoyed the collaboration of some of the most renowned universities and institutes in Europe, including the Max Planck Institute of Experimental Medicine (Germany), the University of Newcastle (United Kingdom), the Institute for Research in Biomedicine (IRB Barcelona), the University of Barcelona (UB), the Central University of Catalonia, the University Medical Center of Göttingen (Germany), ad the Sorbonne University (France).
The research paved the way for new therapies and drugs that can fight better against neurodegenerative diseases such as Parkinson’s disease.
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